Hazrat Maulana Syed Nizamuddin belongs to an educated family. He received his primary education at the hands of his father at home. Afterwards he was admitted at Madarsa Imdadia, Darbhanga for one year in 1941. In 1942 he was sent to Darul Uloom, Deoband for higher education. He studied Hadith there up to 1947. After completion of education, he adopted teaching and joined Madarasa Riyazul Uloom, Sathi District Champaran as its Principal and remained there for 12 years from 1949 to 1962. He joined Madarsa Rasheedul Uloom at Chatra as its Principal and remained there for two years from 1963-1964.

He was identified and chosen by Hazrat Ameer Shariat Maulana Syed Shah Minnatullah Rahmani (Rahamatullah Aley) for the work at Imarat-e-Shariah. Therefore, he joined the Imarat-e-Shariah in 1965 as its Nazim (Administrator). In 1991 he was unanimously elected as the General Secretary of the All India Muslim Personal Law Board after death of Maulana Syed Shah Minnatullah Rahmani (Rahamatullah Aley). He is ably performing these duties till date.

He was elected as Ameer Shariat, Imarat-e-Shariah, Bihar-Orissa and Jharkhand in the year 1998 after death of Hazrat Maulana Abdul Rahman (Rahamatullah Aley).

Hazrat Maulana Syed Nizamuddin took oath of allegiance to Shaikhul Hind Hazrat Maulana Hussain Ahmad Madani (Rahamatullah Aley). He is Shaikhul Hind's disciple as well. He is member of the Majlis-e-Shoora of Darul Uloom, Deoband, and Majlis-e-Muntzama, Darul Uloom Nadwatul Ulema, Lucknow.